VP, mRNA Payload Development

Carcell, Shanghai


Carcell is an EVX company that is building an “assembly line” business model that empowers rapid cell and gene therapy development. Co-founded by biotech veterans and backed by elite VCs, Carcell’s core capabilities cover all essential aspects of drug development including pre-clinical R&D, IP licensing and management, CMC and manufacturing, IND filing and clinical testing. This core platform will support multiple cell and gene therapy programs, with an initial focus on immune-oncology, autoimmune diseases and rare diseases. We believe that Carcell’s model of a centralized cell and gene therapy platform will rapidly and cost-efficiently translate innovative research into successful clinical products.

Carcell has R&D teams, central function teams, and manufacturing infrastructure based in Shanghai, Singapore, and Boston (upcoming).

We are looking for a VP with mRNA payload development expertise to join our R&D team in Shanghai in this exciting venture. An ideal candidate is one who is independent, technically competent, highly motivated, and able to efficiently work across multiple projects.


  • Lead the effort of mRNA payload optimization for liver-targeted LNP delivery, including UTR design, codon optimization, and mRNA chemical modification.

  • Lead process development and scale-up of various mRNA production strategies

  • Provide technical oversight and guidance to improve process

  • Take charge of the recruitment, oversight, and mentoring of a team of development scientists to ensure smooth operations within the team

  • Work cross-functionally to advance mRNA science with external partners

  • Analyze, interpret, and present data to internal and external audience using various formats including lab notebooks and meeting presentations


  • PhD degree and 6 to 12 years’ experience or MS degree with 15 years process development experience in a pharmaceutical or CDMO organization; prior experience with mRNA is highly desirable

  • Hands-on experience running IVT experiments and standard molecular biology techniques (e.g. PCR, cloning, DNA/RNA production, etc.)

  • In-depth understanding of chromatography purification of mRNA, including process scale-up

  • Experience with technology transfer of manufacturing processes; Good understanding of cGMP manufacturing guidelines

  • Understanding of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing is highly desirable

  • Knowledge of key analytical testing of mRNA is highly desirable

  • Proven Leadership, good communication skills and strong work ethic.

To apply for this role, please fill up your information and attach your CV at 


For any enquiries, please email ning.mao@carcell.com

Carcell is an equal opportunity employer and all qualified applicants will receive consideration for employment.