Scientist / Senior Scientist, Molecular Biology
Carcell is an EVX company that is building an “assembly line” business model that empowers rapid cell and gene therapy development. Co-founded by biotech veterans and backed by elite VCs, Carcell’s core capabilities cover all essential aspects of drug development including pre-clinical R&D, IP licensing and management, CMC and manufacturing, IND filing and clinical testing. This core platform will support multiple cell and gene therapy programs, with an initial focus on immune-oncology, autoimmune diseases and rare diseases. We believe that Carcell’s model of a centralized cell and gene therapy platform will rapidly and cost-efficiently translate innovative research into successful clinical products.
Carcell has R&D teams, central function teams, and manufacturing infrastructure based in Shanghai, Singapore, and Boston (upcoming).
We are looking for a Scientist / Senior Scientist with molecular biology background and expertise to join our R&D team in Singapore in this exciting venture. An ideal candidate is one who is technically competent, an effective communicator, and able to manage a team efficiently across multiple projects. This role reports to the Head of Molecular Biology.
Perform independent research work through the design, execution and troubleshooting of experiments
Interface with and manage external collaborators, including CROs, clinical and academic laboratories
Analyze, interpret and report experimental results to the research group and other key stakeholders
Provide scientific expertise, stay up to date on the latest relevant scientific literature, and mentor others in research findings and techniques.
Contribute to scientific and strategy discussions to achieve R&D milestones
Maintain accurate and detailed documentation of research data, inventories, protocols, maintenance logs, sample processing logs, SOPs etc.
Support the continued protection, creation, and expansion of company’s intellectual property
Perform other related duties incidental to the work described herein
PhD in Molecular Biology, Biochemistry, Genetics, Synthetic Biology or a related discipline
2-3 years of postdoctoral and/or industry experience is a plus
Extensive experience with nucleic acid chemistry, molecular cloning, genetic engineering/gene therapy, design of expression cassettes
Familiarity with the use of CRISPR/Cas9 gene editing, next-generation sequencing, LNPs, immunology (flow cytometry) will be an advantage
Experienced in general laboratory techniques that include mammalian cell transfection and handling, bacterial transformation, molecular assays (such as qPCR, ELISA, Western blot), nucleic acid extraction, purification and characterization (DNA & RNA)
Experienced in mouse work/in vivo animal models
Able to work in a fast-paced startup environment; Flexible, adaptable and adjusts quickly to changing strategic and tactical priorities