VP, mRNA Payload Development
Carcell is an EVX company that is building an “assembly line” business model that empowers rapid cell and gene therapy development. Co-founded by biotech veterans and backed by elite VCs, Carcell’s core capabilities cover all essential aspects of drug development including pre-clinical R&D, IP licensing and management, CMC and manufacturing, IND filing and clinical testing. This core platform will support multiple cell and gene therapy programs, with an initial focus on immune-oncology, autoimmune diseases and rare diseases. We believe that Carcell’s model of a centralized cell and gene therapy platform will rapidly and cost-efficiently translate innovative research into successful clinical products.
Carcell has R&D teams, central function teams, and manufacturing infrastructure based in Shanghai, Singapore, and Boston (upcoming).
We are looking for a VP with mRNA payload development expertise to join our R&D team in Shanghai in this exciting venture. An ideal candidate is one who is independent, technically competent, highly motivated, and able to efficiently work across multiple projects.
Lead the effort of mRNA payload optimization for liver-targeted LNP delivery, including UTR design, codon optimization, and mRNA chemical modification.
Lead process development and scale-up of various mRNA production strategies
Provide technical oversight and guidance to improve process
Take charge of the recruitment, oversight, and mentoring of a team of development scientists to ensure smooth operations within the team
Work cross-functionally to advance mRNA science with external partners
Analyze, interpret, and present data to internal and external audience using various formats including lab notebooks and meeting presentations
PhD degree and 6 to 12 years’ experience or MS degree with 15 years process development experience in a pharmaceutical or CDMO organization; prior experience with mRNA is highly desirable
Hands-on experience running IVT experiments and standard molecular biology techniques (e.g. PCR, cloning, DNA/RNA production, etc.)
In-depth understanding of chromatography purification of mRNA, including process scale-up
Experience with technology transfer of manufacturing processes; Good understanding of cGMP manufacturing guidelines
Understanding of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing is highly desirable
Knowledge of key analytical testing of mRNA is highly desirable
Proven Leadership, good communication skills and strong work ethic.
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Carcell is an equal opportunity employer and all qualified applicants will receive consideration for employment.