Scientist, Preclinical (Mouse) Disease Models (Nuevocor Singapore)

EVX Ventures, Singapore

Description

Nuevocor is a pre-clinical stage biopharmaceutical start-up dedicated to developing gene therapies to treat the underlying cause of genetic cardiomyopathies. Backed by an international syndicate of reputable venture capital firms, it will focus on advancing its lead program to clinical trials. It will also leverage its platform technology, underpinned by a deep understanding of cardiac cell biology and novel cardiotropic viral vectors, to discover and develop therapies for genetic cardiomyopathies. We are an equal opportunity employer that offers competitive salary and benefits. Nuevocor’s Singapore R&D site is looking for a highly motivated pre-clinical disease models scientist to join the team.

Responsibilities

  • Independently design, execute and troubleshoot experiments to design, develop and phenotype mouse models of cardiomyopathy 

  • Determine efficacy of gene therapy strategies for mouse models of cardiomyopathy 

  • Contribute to design of cardiac gene therapies 

  • Document and interpret data to develop and improve experimental procedures 

  • Contribute to joint projects internally and actively participate in external academic and industrial collaborations 

  • Communicate with and manage scientific collaborators to achieve project milestones 

  • Keep detailed and accurate records of experiments, data and analysis to support and protect intellectual property of the company 

  • Prepare and present scientific updates internally and externally 

  • Basic lab management duties

Requirements

  • PhD in Developmental Biology, Physiology, or related fields 

  • Extensive expertise in working with mouse models(physiology, administration of drugs, tissue extraction, processing, histology, and molecular and biochemical analysis) 

  • Strong understanding of and experience in mouse genetics and mouse disease models, including design of gene targeting constructs, engineering and use of transgenic mouse disease models and colony management 



Preferred qualifications :

  • Experience in analysis of mouse cardiac physiology, such as ultrasound echocardiography is highly advantageous 

  • Experience with AAV gene therapy is desirable 

  • Good understanding of molecular biology, particularly in the design of gene expression constructs, would be advantageous. 

  • Experience with cell biological assays such as immunofluorescence and confocal microscopy is preferred 

  • Keen interest in translational research and comfortable working efficiently to meet milestones 

  • High standards in documentation 

  • Good time management and pro-active attitude 

  • Excellent communication skills and able to work in a team


Interested candidates, please submit a CV and cover letter to http://tinyurl.com/nuevocorcareers


Nuevocor is an equal opportunity employer and all qualified applicants will receive consideration for employment.

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SINGAPORE

LaunchPad @ one-north

71 Ayer Rajah Crescent

#03-20/21/23/24

Singapore 139951

UNITED STATES

Cambridge Innovation Center

One Broadway, Kendall Square

Cambridge MA 02142

CHINA

Biotech Innovation Works

No.29 Life Park Road

Room 202-010, Block D

Changping District, Beijing, China, 102206

© 2021 by EVX Ventures Pte. Ltd.